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課程名稱 |
藥物傳輸系統
DRUG DELIVERY SYSTEMS |
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開課學期 |
99-1 |
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授課對象 |
工學院 醫學工程學研究所 |
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授課教師 |
黃義侑 |
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課號 |
Biomed7014 |
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課程識別碼 |
548 M0300 |
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班次 |
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學分 |
3 |
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全/半年 |
半年 |
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必/選修 |
選修 |
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上課時間 |
星期四2,3,4(9:10~12:10) |
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上課地點 |
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備註 |
本課程中文授課,使用英文教科書。本課程中文授課,使用英文教科書。教室：基醫505
總人數上限：30人 |
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Ceiba 課程網頁 |
http://ceiba.ntu.edu.tw/991Biomed7014 |
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課程簡介影片 |
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核心能力關聯 |
核心能力與課程規劃關聯圖 |
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課程大綱
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課程概述 |
一、課程簡介:
To provide the students with a broad spectrum of scientific information in a concise, systematic manner but with new vision and wider scope in drug delivery systems. Lectures include:
1. Concepts and System Design forthe Rate-Controlled Drug Delivery
2. Mathematical Modeling of Controlled Drug Delivery
3. Oral Drug Delivery and Delivery System
4. Mucosal Drug Delivery: Potential Routes for Noninvasive Systemic
Administration (Rectal & Oral musosa DDS)
5. Nasal/ Pulmonary Drug Delivery and Delivery System
6. Transdermal Drug Delivery and Delivery System
7. Ocular Drug Delivery and Delivery System
8. Polymers for Drug delivery, EVA, Silicone...
and Natural Biodegradable Polymer in Drug Delivery System
9. Synthetic Biodegradable Polymer in Drug Delivery System
10. Compartmental Models and Their Application
11. Drug Targeting
12. Liposome Drug Delivery
13. Study Report
二、先修課程:無
三、參考書目:
1. H. C. Ansel and N. G. Popovich “Pharmaceutical Dosage Forms and drug Delivery System” Lea & Febiger Philadelphia, 6th Ed 1995
2. Y.W. Chien `Novel Drug Delivery Systems` 1992 Marcel Dekker Inc,
3. C.G. Wilson and N. Washington “ Physiological Pharmaceutics : Biological Barriers to Drug Absorption” 1989 Ellis Horwood Limited
4. 橋田 充 “生體內藥物送達學”
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課程目標 |
Introduction to the application of engineering principles and biological considerations in designing drug delivery systems for medical uses.
The concept of biocompatibility and its implications in formulating controlled release devices will be illustrated. Emphasis will be given to the use of biodegradable materials to design drug delivery systems for site-specific applications. The concepts of mathematical modeling of controlled release drug delivery systems will be covered.
And to provide the students with a broad spectrum of scientific information in a concise, systematic manner but with new vision and wider scope in drug delivery systems.
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課程要求 |
無 |
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預期每週課後學習時數 |
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Office Hours |
另約時間 |
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指定閱讀 |
1. A.M. Hillery, A.W. Lloyd, J. Swarbrick “Drug delivery and Targeting for Pharmacists and Pharmaceutical Scientists” Taylor & Francis, 2001
2. L.V. Allen, N. G. Popovich, H. C. Ansel “Pharmaceutical Dosage Forms and drug Delivery System” Lippincott Williams & Wilkins, 8th ed c2005
3. Drug delivery : principles and applications / Binghe Wang, Teruna Siahaan, Richard Soltero Wiley-Interscience, c2005
4. Enhancement in drug delivery / edited by Elka Touitou, Brian W. Barry Boca Raton : CRC Press, c2007
5. Design of controlled release drug delivery systems / [edited by] Xiaoling Li, Bhaskara R. Jasti New York : McGraw-Hill, c2006
RS201.C64 D47
6. Y.W. Chien “Novel Drug Delivery Systems” 1992 Marcel Dekker Inc. 7. 橋田 充 “生體內藥物送達學”
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參考書目 |
Drug targeting: strategies principle &.. 2000
Controlled drug delivery: Challenge and Strategies Ed. Kinam Park, 1997 WB340
C764
Protein formulation and delivery Ed. Eugene J. McNally 2000 W1, D842
Transport processes in in pharmaceutical systems 2000 W1 D842p
Biomimetic materials and design 2002
Pardridge, W Brain drug targeting:the future of brain drug develop 2001
QV76.5 P226
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評量方式
(僅供參考) |
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No. |
項目 |
百分比 |
說明 |
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1. |
平時考 |
50% |
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2. |
期中考 |
25% |
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3. |
期末報告及書面報告 |
25% |
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週次 |
日期 |
單元主題 |
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第1週 |
9/16 |
Drug Delivery: The Basic Concepts |
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第2週 |
9/23 |
Drug Delivery: Market Perspectives |
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第3週 |
9/30 |
Advanced Drug Delivery and Targeting: An Introduction |
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第4週 |
10/07 |
Rate Control in Drug Delivery and Targeting: Fundamentals and Applications to Implantable Systems |
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第5週 |
10/14 |
Drug Targeting Systems: Fundamentals and Applications to Parenteral Drug Delivery |
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第6週 |
10/21 |
Drug Targeting Systems: Fundamentals and Applications to Parenteral Drug Delivery |
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第7週 |
10/28 |
Oral Drug Delivery |
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第8週 |
11/04 |
期中考 |
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第9週 |
11/11 |
Oral Trans-mucosal Drug Delivery |
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第10週 |
11/18 |
Transdermal Drug Delivery |
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第11週 |
11/25 |
Nasal Drug Delivery |
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第12週 |
12/02 |
Pulmonary Drug Delivery(8458) |
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第13週 |
12/09 |
Vaginal Drug Delivery |
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第14週 |
12/16 |
Ophthalmic Drug Delivery |
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第15週 |
12/23 |
Drug Delivery to the Central Nervous System |
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第16週 |
12/30 |
Plasmid-based Gene Therapy
Integrating Drug Discovery and Delivery
New Generation Technologies |
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第17週 |
1/06 |
期末報告 |
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